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CY-09 is a selective, direct small-molecule inhibitor of the NLRP3 inflammasome that binds the ATP-binding motif of the NLRP3 NACHT domain, inhibiting NLRP3 ATPase activity and suppressing inflammasome assembly and activation. It is supplied as a solid for research use in studies of inflammatory signaling and innate immunity.
Selective NLRP3 inhibitor that binds the NLRP3 ATP-binding motif.
Inhibits NLRP3 ATPase activity to block inflammasome assembly.
Applicable to research on inflammation, innate immunity, and disease models.
Solid, light yellow to yellow appearance; high purity suitable for biochemical assays.
Recommended storage: powder at -20°C for long term stability.
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CY 208-243 is a selective dopamine D1 receptor agonist that demonstrates antiparkinsonian activity. It is intended for research purposes only. In vivo studies show that pretreatment with CY 208-243 prevents the increase of dopamine (DA) release and metabolism induced by the D-1 antagonist, SCH 23390.
Selective dopamine D1 receptor agonist
Exhibits antiparkinsonian activity
Prevents increase of DA release and metabolism
For research use only
Appearance: Solid, white to off-white
Solubility (in vitro): DMSO: 50 mg/mL
Storage (powder): -20°C for 3 years, 4°C for 2 years
Storage (in solvent): -80°C for 6 months, -20°C for 1 month
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Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Cynomolgus (Biotinylated) is a biotinylated recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E coli
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IL-2R beta (CD122) a type cytokine receptor expressed on T lymphocytes is a receptor for IL-2 (Kd 1 nM approximately)[1] IL-2R beta mediates T cell immune responses such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2] IL-2R beta/CD122 Protein Cynomolgus (HEK293 His) is a recombinant cynomolgus IL-2R beta (A27-D239) with a C-Terminal His tag which is produced in HEK 293
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RK-701 is a highly selective potent and low-toxicity inhibitor of histone methyltransferases G9a and GLP1 with IC50 values of 23-27 nM and 53 nM RK-701 treatment induces fetal globin expression in human erythroid cells and in mice and plays an essential role in -globin induction RK-701 is used in the research of sickle cell disease
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CY-09 is a selective, direct inhibitor of the NLRP3 inflammasome used for biochemical and cellular research. It binds the ATP-binding motif of the NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, preventing inflammasome assembly and activation. For research use only.
Selective NLRP3 inhibitor targeting the NACHT domain
Inhibits NLRP3 ATPase activity to block inflammasome activation
High purity compound suitable for biochemical and cellular assays
Available as a solid powder, stable under recommended storage conditions
Supplied in research-scale pack sizes for laboratory experiments
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SP Sepharose(R) Fast Flow is a strong cation exchanger based on the well established Sepharose(R) Fast Flow ion exchange platform extensively used for preparative protein separations in both research and industrial applications.SP Sepharose(R) Fast Flow is part of the Sepharose(R) Fast Flow ion exchange platform which has been the industrial standard for ion exchange chromatography during recent decades. It is composed of crosslinked 6% agarose beads with sulphopropyl (Q) strong cation exchange groups. SP Sepharose(R) Fast Flow has high chemical stability allowing well proven cleaning-in-place (CIP) and sanitization protocols. Scale-up with SP Sepharose(R) Fast Flow is straight forward and the medium is available in a range of pre-packed process development tools.As member of the BioProcess media range SP Sepharose(R) Fast Flow meets industrial demands with security of supply and comprehensive technical and regulatory support.
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Fluorescent In Situ Hybridization technique (FISH) is based on the hybridization of fluorescent labeled oligonucleotide probe to a specific complementary DNA or RNA sequence in whole and intact cells.1 Microbial FISH allows the visualization identification and isolation of bacteria due to recognition of ribosomal RNA also in unculturable samples.2 FISH technique can serve as a powerful tool in the microbiome research field by allowing the observation of native microbial populations in diverse microbiome environments such as samples from human origin (blood3 and tissue4) microbial ecology (solid biofilms5 and aquatic systems6) and plants7. Prokaryotic single cell life forms are divided into two domains called Bacteria and Archaea originally categorized as Eubacteria and Archaebacteria.8 However both terms Eubacteria and Bacteria are still being used in microbiology.Eubacteria probe recognizes most bacteria as it is complementary to a portionof 16S rRNA found in almost all bacteria
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